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The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage,Facilitating Double-Strand Break Repair
Authors:Keren Baranes-Bachar  Adva Levy-Barda  Judith Oehler  Dylan A Reid  Isabel Soria-Bretones  Ty C Voss  Dudley Chung  Yoon Park  Chao Liu  Jong-Bok Yoon  Wei Li  Graham Dellaire  Tom Misteli  Pablo Huertas  Eli Rothenberg  Kristijan Ramadan  Yael Ziv  Yosef Shiloh
Institution:1. The David and Inez Myers Laboratory for Cancer Research, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;2. Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK;3. Perlmutter NYU Cancer Center and Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA;4. Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) and Department of Genetics, University of Sevilla, Sevilla, Spain;5. National Cancer Institute, NIH, Bethesda, MD, USA;6. Departments of Pathology and Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada;7. Department of Biochemistry and Protein Network Research Center, Yonsei University, 134 Shinchon-Dong, Seodaemoon-Gu, Seoul, Korea;8. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Abstract:
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  • Keywords:genome stability  DNA damage  double-strand breaks  ubiquitin  UBE4A
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