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Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs
Authors:Denise R. Minton  Minwoo Nam  Daniel J. McLaughlin  Jong Shin  Erol C. Bayraktar  Samantha W. Alvarez  Vladislav O. Sviderskiy  Thales Papagiannakopoulos  David M. Sabatini  Kıvanç Birsoy  Richard Possemato
Affiliation:1. Department of Pathology, NYU School of Medicine, New York, NY 10016, USA;2. Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA;3. Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA;4. Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA;5. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;6. David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA;7. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;8. Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, MA 02142, USA
Abstract:
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  • Keywords:SHMT2  serine  one-carbon metabolism  formylmethionine  metabolism
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