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Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2
Authors:Alessandro Annibaldi  Sidonie Wicky John  Tom Vanden Berghe  Kirby N. Swatek  Jianbin Ruan  Gianmaria Liccardi  Katiuscia Bianchi  Paul R. Elliott  Sze Men Choi  Samya Van Coillie  John Bertin  Hao Wu  David Komander  Peter Vandenabeele  John Silke  Pascal Meier
Affiliation:1. The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK;2. VIB Center for Inflammation Research, Ghent, Belgium;3. Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium;4. Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK;5. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Room 3024B, 3 Blackfan Circle, Boston, MA 02115, USA;6. Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK;7. Pattern Recognition Receptor DPU and Platform Technology and Science, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA;8. The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia;9. Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia
Abstract:
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  • Keywords:TNF  cIAPs  ubiquitin  RIPK1  cell death  apoptosis  necroptosis  caspase-8  inflammation
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