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Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions |
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| Authors: | Thuy P Dao Regina-Maria Kolaitis Hong Joo Kim Kevin O’Donovan Brian Martyniak Erica Colicino Heidi Hehnly J Paul Taylor Carlos A Castañeda |
| Institution: | 1. Departments of Biology and Chemistry, Syracuse University, Syracuse, NY 13244, USA;2. Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA;3. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA;4. Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA |
| Abstract: |  |
| Keywords: | Ubiquilin-2 stress granules multivalent interactions ubiquitin protein quality control liquid-liquid phase separation LLPS NMR spectroscopy ligand-induced phase transition amyotrophic lateral sclerosis |
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