Predicting functional upstream open reading frames in Saccharomyces cerevisiae |
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| Authors: | Selpi Christopher H Bryant Graham JL Kemp Janeli Sarv Erik Kristiansson and Per Sunnerhagen |
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| Institution: | (1) Department of Applied Mechanics, Chalmers University of Technology, SE-412 96 G?teborg, Sweden;(2) School of Computing, Science and Engineering, University of Salford, Salford, M5 4WT, UK;(3) Department of Computer Science and Engineering, Chalmers University of Technology, SE-412 96 G?teborg, Sweden;(4) Department of Mathematical Sciences, Chalmers University of Technology and the University of Gothenburg, SE-412 96 G?teborg, Sweden;(5) Department of Zoology, University of Gothenburg, Box 463, SE-405 30 G?teborg, Sweden;(6) Department of Cell and Molecular Biology, Lundberg Laboratory, University of Gothenburg, PO BOX 462, SE-405 30 G?teborg, Sweden |
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| Abstract: | Background Some upstream open reading frames (uORFs) regulate gene expression (i.e., they are functional) and can play key roles in keeping
organisms healthy. However, how uORFs are involved in gene regulation is not yet fully understood. In order to get a complete
view of how uORFs are involved in gene regulation, it is expected that a large number of experimentally verified functional
uORFs are needed. Unfortunately, wet-experiments to verify that uORFs are functional are expensive. |
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