Characterization of the mechanical properties of bovine cortical bone treated with a novel tissue sterilization process |
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Authors: | Nathan Kemper Noel Davison Daniel Fitzpatrick Rebecca Marshall Albert Lin Katherine Mundy Ronald R Cobb |
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Institution: | (1) Spine, Orthopedics, and Dental Research and Development Group, RTI Biologics, Inc, 11621 Research Circle, Alachua, FL 32615, USA; |
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Abstract: | Over the past decade chemical processing and engineering of musculoskeletal tissue (tendon and bone) has improved dramatically. The use of bone allograft and xenograft in reconstructive orthopedic and maxillofacial surgeries is increasing, yet severe complications can occur if the material is contaminated in any way. A novel tissue sterilization process, BioCleanse®, has been developed to clean and sterilize musculoskeletal tissue for implantation. The present study was designed to determine the effect of this novel cleaning process on the biomechanical properties of bovine cortical bone prior to implantation. The mechanical properties of treated bovine bone material were compared to human samples with respect to failure under compression, shear and three-point bending. The data demonstrate that bovine bone treated with the novel sterilization procedure has favorable biomechanical properties compared to that of human bone treated in a similar fashion. |
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