A high-throughput pipeline for the design of real-time PCR signatures |
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| Authors: | Ravi Vijaya Satya Kamal Kumar Nela Zavaljevski Jaques Reifman |
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| Institution: | (1) Biotechnology HPC Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD 21702, USA |
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| Abstract: | Background Pathogen diagnostic assays based on polymerase chain reaction (PCR) technology provide high sensitivity and specificity. However,
the design of these diagnostic assays is computationally intensive, requiring high-throughput methods to identify unique PCR
signatures in the presence of an ever increasing availability of sequenced genomes. |
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