The long journey to a Systems Biology of neuronal function |
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Authors: | Nicolas Le Novère |
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Institution: | (1) EMBL-EBI, Wellcome-Trust Genome Campus, CB10 1SD Hinxton, UK |
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Abstract: | Computational neurobiology was born over half a century ago, and has since been consistently at the forefront of modelling
in biology. The recent progress of computing power and distributed computing allows the building of models spanning several
scales, from the synapse to the brain. Initially focused on electrical processes, the simulation of neuronal function now
encompasses signalling pathways and ion diffusion. The flow of quantitative data generated by the "omics" approaches, alongside
the progress of live imaging, allows the development of models that will also include gene regulatory networks, protein movements
and cellular remodelling. A systems biology of brain functions and disorders can now be envisioned. As it did for the last
half century, neuroscience can drive forward the field of systems biology. |
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