A canonical FtsZ protein in <Emphasis Type="Italic">Verrucomicrobium spinosum</Emphasis>, a member of the Bacterial phylum <Emphasis Type="Italic">Verrucomicrobia</Emphasis> that also includes tubulin-producing <Emphasis Type="Italic">Prosthecobacter</Emphasis> species |
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Authors: | Benjamin Yee Feras F Lafi Brian Oakley James T Staley John A Fuerst |
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Institution: | (1) School of Molecular and Microbial Sciences, University of Queensland, 4072 Brisbane, Queensland, Australia;(2) Department of Microbiology, University of Washington, 98195 Seattle, WA, USA |
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Abstract: | Background The origin and evolution of the homologous GTP-binding cytoskeletal proteins FtsZ typical of Bacteria and tubulin characteristic
of eukaryotes is a major question in molecular evolutionary biology. Both FtsZ and tubulin are central to key cell biology
processes – bacterial septation and cell division in the case of FtsZ and in the case of tubulins the function of microtubules
necessary for mitosis and other key cytoskeleton-dependent processes in eukaryotes. The origin of tubulin in particular is
of significance to models for eukaryote origins. Most members of domain Bacteria possess FtsZ, but bacteria in genus Prosthecobacter of the phylum Verrucomicrobia form a key exception, possessing tubulin homologs BtubA and BtubB. It is therefore of interest to know whether other members
of phylum Verrucomicrobia possess FtsZ or tubulin as their FtsZ-tubulin gene family representative. |
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