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Francisella strains express hemolysins of distinct characteristics |
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| Authors: | Lai Xin-He Wang Su-Yan Edebro Helen Sjöstedt Anders |
| Institution: | 1. Departament de Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain;2. Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Parc Científic, Universitat de València, PO Box 22085, 46071 Valencia, Spain;3. Laboratorio de Necton, El Colegio de la Frontera Sur (ECOSUR), Unidad Chetumal, Chetumal, Quintana Roo, Mexico;4. Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Brani?ovska 31, 370 05 ?eské Budějovice, Czech Republic |
| Abstract: | Historically, Francisella strains have been described as nonhemolytic. In this study, we show by use of solid and liquid hemolysis assays that some Francisella strains have hemolytic properties. The Francisella novicida type strain U112 is hemolytic to horse erythrocytes and Francisella philomiragia type strain FSC144 is hemolytic towards both human and horse erythrocytes. The F. novicida strain U112 released a protein (novilysin A) into the culture supernatant which cross-reacted with antiserum against Escherichia coli HlyA whereas there was no similar protein detectable with this cross-reactive property from the supernatant of the F. philomiragia strain. |
| Keywords: | Hemolysin Novilysin A Virulence factor Growth-phase dependence Francisella |
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