Construction of original artificial immunogens--candidate vaccines against HIV-1 |
| |
| Authors: | Lebedev L R Gileva I P Karpenko L I Eroshkin A M |
| |
| Affiliation: | State Virology and Biotechnology Center Vektor, Berdsk, Novosibirsk region. |
| |
| Abstract: | An original method for making effective artificial vaccines has been developed. Immunogens are virus-like particles containing a DNA molecule covered with recombinant proteins carrying the pathogen epitopes. The recombinant proteins are exposed on the surface of the particle and are attached to DNA via spermidine-polygluquine-glutathione or galactopyranoside conjugates (depending on the hybrid protein composition). Two variants of artificial immunogens-candidates for antiHIV vaccine have been prepared. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
