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ABO blood group polymorphisms and risk for ischemic stroke and peripheral arterial disease
Authors:Adriano de Paula Sabino  Daniel Dias Ribeiro  Caroline Pereira Domingheti  Danyelle Romana Alves Rios  Luci Maria SantAna Dusse  Maria das Graças Carvalho  Ana Paula Fernandes
Institution:1. Faculty of Pharmacy, Federal University of Minas Gerais, Av. Ant?nio Carlos 6627, Pampulha, Belo Horizonte, MG, Brazil
2. University Hospital–Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
3. Health Sciences Center, Federal University of S?o Jo?o Del Rei, Divinópolis, MG, Brazil
Abstract:Recent studies have demonstrated association between ABO blood system and thrombosis, indicating that individuals belonging to non-O blood groups (A, B or AB) present an increased risk of venous thrombosis, heart disease, and ischemic stroke (IS) as compared to O blood group carriers. In this study, we investigated the frequency of ABO blood group polymorphisms and its association with IS and peripheral arterial disease. Significant differences were observed for O1 (OR 0.57, 95 % CI 0.35–0.95, p < 0.05) and O2 (OR 3.47, 95 % CI 1.15–10.28, p < 0.05) alleles among IS patients while significant differences were observed for B phenotype (26.3 vs 9.5 %, OR 3.42, 95 % CI 1.32–8.76, p = 0.01, patients vs controls, respectively) and alleles A1 (OR 0.31, 95 % CI 0.11–0.84, p < 0.05), O2 (OR 4.61, 95 % CI 1.59–13.23, p < 0.01) and B (OR 3.42, 95 % CI 1.62–7.13, p < 0.001) alleles for PAD patients. O1 allele was an independent variable (OR 0.27, 95 % CI 0.12–0.57, p < 0.001) for IS patients. These data suggest the relationship of non-O blood groups in pathogenesis of thrombosis events and a possible protective effect of O blood group.
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