远端霉素高产菌株的选育

目的：选育远端霉素高产菌株。方法：以远端霉素产生菌（Streptomyces distallicus）D32为出发菌株，经铜蒸汽激光和5-氟尿嘧啶（5-fu）及其复合处理。结果：在复合诱变组中获得一株远端霉素高产稳产突变株DZ-206，经发酵罐应用后，其产率较出发菌株提高1．38倍。结论：该方法诱变谱广，突变率高，能够快速有效获得抗生素高产菌株。

Selection of High Distamycin Producing Strain

Objeive： Selection of distamycin high-producing strain. Method： After Streptomyces distallicus D32 was treated by copper vapor laser irradiation and 5-fluorouracil. Result：A high-producing strain DZ-206 was obtained. It stability increased, the yield of fermentation reached to 1.38 times of parent strain in tank of fermentation. Conclusion ： This method has a broad spectrum of mutation, the mutation rateis high, fast and effective to obtain high yield antibiotic strain.