Modeling of loops in proteins: a multi-method approach |
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Authors: | Michal Jamroz Andrzej Kolinski |
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Affiliation: | (1) Laboratory of Theory of Biopolymers, Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland |
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Abstract: | Background Template-target sequence alignment and loop modeling are key components of protein comparative modeling. Short loops can be predicted with high accuracy using structural fragments from other, not necessairly homologous proteins, or by various minimization methods. For longer loops multiscale approaches employing coarse-grained de novo modeling techniques should be more effective. |
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