Angiotensin II upregulates the expression of placental growth factor in human vascular endothelial cells and smooth muscle cells |
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| Authors: | Pingxi Pan Hua Fu Lingjun Zhang He Huang Fengming Luo Wenchao Wu Yingqiang Guo Xiaojing Liu |
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| Affiliation: | (1) Laboratory of Cardiovascular Diseases, National key Laboratory of Biotherapy of Human Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China;(2) Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, China;(3) Golden-card ward, West China Hospital, Sichuan University, Chengdu, 610041, China;(4) Department of Thoracic & Cardiovascular surgery, West China Hospital, Sichuan University, Chengdu, 610041, China |
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| Abstract: | Background Atherosclerosis is now recognized as a chronic inflammatory disease. Angiotensin II (Ang II) is a critical factor in inflammatory responses, which promotes the pathogenesis of atherosclerosis. Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family cytokines and is associated with inflammatory progress of atherosclerosis. However, the potential link between PlGF and Ang II has not been investigated. In the current study, whether Ang II could regulate PlGF expression, and the effect of PlGF on cell proliferation, was investigated in human vascular endothelial cells (VECs) and smooth muscle cells (VSMCs). |
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