| 脂连素对小鼠急性肝损伤的保护作用 |
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| 引用本文： | 尹洪竹,曹治宸,赵彩彦,甄真,周俊英. 脂连素对小鼠急性肝损伤的保护作用[J]. 中国组织化学与细胞化学杂志, 2008, 17(2): 156-159. DOI: 10.3870/j.issn.1004-1850.2008.02.008 |
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| 作者姓名： | 尹洪竹 曹治宸 赵彩彦 甄真 周俊英 |
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| 作者单位： | 河北医科大学第三医院感染科,石家庄,050051 |
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| 摘 要： | 目的观察脂连素对刀豆蛋白A（ConA）所致小鼠急性肝损伤的干预作用，并对其机制进行初步探讨。方法雄性BALB／C小鼠17只，随机分为3组：ConA组6只：尾静脉注射ConA。脂连素组5只：在静脉注射ConA前腹腔内注射脂连素。对照组6只：尾静脉注射生理盐水。注射ConA后8小时留取血清检测各组ALT和TNF-α水平，肝组织进行HE染色，并检测NF-κB活性及肝细胞凋亡率。结果HE染色可见ConA组肝细胞水肿、变性，肝组织内淋巴细胞浸润、淤血等，脂连素组上述病理变化减轻（P〈0．01）。脂连素组ALT和TNF-α水平、NF-κB活性、肝细胞凋亡率均低于ConA组（P〈0．01或P〈0．05）。结论脂连素具有抗炎作用，其机制可能与减少TNF-α的产生、抑制肝组织NF-κB活性及抗肝细胞凋亡有关。
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| 关 键 词： | 脂连素 肝细胞凋亡 核因子-κB活性 刀豆蛋白A 急性肝损伤 |
| 修稿时间： | 2007-08-10 |
PROTECTIVE EFFECTS OF ADIPONECTIN ON ACUTE HEPATIC INJURY IN MICE |
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| Yin Hongzhu,Cao Zhichen,Zhao Caiyan,Zhen Zhen,Zhou Junying. PROTECTIVE EFFECTS OF ADIPONECTIN ON ACUTE HEPATIC INJURY IN MICE[J]. Chinese Journal of Histochemistry and Cytochemistry, 2008, 17(2): 156-159. DOI: 10.3870/j.issn.1004-1850.2008.02.008 |
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| Authors: | Yin Hongzhu Cao Zhichen Zhao Caiyan Zhen Zhen Zhou Junying |
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| Affiliation: | Yin Hongzhu,Cao Zhichen,Zhao Caiyan,Zhen Zhen,Zhou Junying(Department of Infectious Disease,The Third Affiliated Hospital,Hebei Medical University,Shijiazhuang 050051,China) |
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| Abstract: | Objective To investigate the role and the mechanism of adiponectin in acute liver injury of mice induced by concanavalin A(ConA).Methods 17 male BALB/c mice were divided randomly in to three groups:ConA group(6 mice)where ConA was intravenously(i.v.)injected ;adiponectin group(5 mice)where adiponectin was intraperitoneally(i.p.)injected before ConA injection;control group(6 mice)where normal saline was i.v.injected.Eight hours after ConA injection,mice were sacrificed,and a single liver segment and blood we... |
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| Keywords: | Adiponectin Hepatocellular apoptosis NF-κB binding activity Concanavalin A Acute liver injury |
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