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Synthesis and antidyslipidemic activity of chalcone fibrates |
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| Authors: | Shukla Poonam Srivastava Swayam P Srivastava Rohit Rawat Arun K Srivastava Arvind K Pratap Ram |
| Institution: | a Medicinal and Process Chemistry, Central Drug Research Institute, MG Marg, Lucknow 226001, India b Division of Biochemistry, Central Drug Research Institute, MG Marg, Lucknow 226001, India |
| Abstract: | A series of chalcone based PPAR-α agonists were synthesized and evaluated for their antidyslipidemic activity in high fructose high fat fed dyslipidemic Syrian golden hamsters. Most of the compounds exhibited antidyslipidemic activity. The compounds 4c and 4f have been identified as most potent antidyslipidemics. A definite structure-activity relationship was observed while varying the nature as well as the position of the substituent. |
| Keywords: | Chalcones Fibrate Antidyslipidaemic activity High fructose high fat diet (HFD) Syrian golden hamsters |
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