Synthesis and antifungal activity of functionalized 2,3-spirostane isomers |
| |
Authors: | Upadhyay Sunil Kumar Creech Clinton C Bowdy Katharine L Stevens Edwin D Jursic Branko S Neumann Donna M |
| |
Institution: | a Department of Chemistry, University of New Orleans, New Orleans, LA 70148, United States b Louisiana State University Health Sciences Center, Department of Ophthalmology, 2020 Gravier St. STE B, New Orleans, LA 70112, United States c Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido St. New Orleans, LA. 70112, United States |
| |
Abstract: | Invasive fungal infections are a major complication for individuals with compromised immune systems. One of the most significant challenges in the treatment of invasive fungal infections is the increased resistance of many organisms to widely used antifungals, making the development of novel antifungal agents essential. Many naturally occurring products have been found to be effective antimicrobial agents. In particular, saponins with spirostane glycosidic moieties—isolated from plant or marine species—have been shown to possess a range of antimicrobial properties. In this report, we outline a novel approach to the synthesis of a number of functionalized spirostane molecules that can be further used as building blocks for novel spirostane-linked glycosides and present results from the in vitro screenings of the antifungal potential of each derivative against four fungal species, including Candida albicans, Cryptococcus neoformans, Candida glabrata, and the filamentous fungus Aspergillus fumigatus. |
| |
Keywords: | Spirostanes Antifungal compounds |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|