Synthesis and antibacterial activity of alaremycin derivatives for the porphobilinogen synthase |
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| Authors: | Iwai Noritaka Nakayama Kyosuke Oku Jumpei Kitazume Tomoya |
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| Institution: | Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan |
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| Abstract: | The preparation and the antibacterial activity of alaremycin derivatives such as their CF3-derivatives and (R)- and (S)-4-oxo-5-acetylaminohexanoic acid for the porphobilinogen synthase (PBGS), were described. The IC50 values of the antibacterial activity of the prepared materials for the inhibitor of PBGS, were determined using PBGS assay. |
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| Keywords: | Porphobilinogen synthase Assay CF3-alaremycin derivatives IC50 |
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