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Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists |
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| Authors: | Cheong Siew Lee Federico Stephanie Venkatesan Gopalakrishnan Paira Priyankar Shao Yi-Ming Spalluto Giampiero Yap Chun Wei Pastorin Giorgia |
| Affiliation: | a Department of Pharmacy, National University of Singapore, 3 Science Drive 2, Block S15, #05-PI-03, Singapore 117543, Singapore b Dipartimento di Scienze Farmaceutiche, Università degli Studi di Trieste, Piazzale Europa 1, I-34127 Trieste, Italy c Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Block S7, #02-06, Singapore 117543, Singapore |
| Abstract: | |
| Keywords: | CoMFA, comparative molecular field analysis cAMP, cyclic adenosine monophosphate ECL2, extracellular loop 2 GPCR, G protein-coupled receptor hA3AR, human A3 adenosine receptor MAPK, mitogen-activated protein kinase MOE, molecular operating environment PLS, partial-least-square PQ, pyrazoloquinolines PTP, pyrazolo-triazolo-pyrimidines TBT, triazolobenzotriazinones TM, transmembrane TP, triazolopyrazinones TQX, triazoloquinoxalinones |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |