|
|||||
|
|
Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists |
|
| Authors: | Cheong Siew Lee Federico Stephanie Venkatesan Gopalakrishnan Paira Priyankar Shao Yi-Ming Spalluto Giampiero Yap Chun Wei Pastorin Giorgia |
| Institution: | a Department of Pharmacy, National University of Singapore, 3 Science Drive 2, Block S15, #05-PI-03, Singapore 117543, Singapore b Dipartimento di Scienze Farmaceutiche, Università degli Studi di Trieste, Piazzale Europa 1, I-34127 Trieste, Italy c Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Block S7, #02-06, Singapore 117543, Singapore |
| Abstract: | |
| Keywords: | CoMFA comparative molecular field analysis cAMP cyclic adenosine monophosphate ECL2 extracellular loop 2 GPCR G protein-coupled receptor hA3AR human A3 adenosine receptor MAPK mitogen-activated protein kinase MOE molecular operating environment PLS partial-least-square PQ pyrazoloquinolines PTP pyrazolo-triazolo-pyrimidines TBT triazolobenzotriazinones TM transmembrane TP triazolopyrazinones TQX triazoloquinoxalinones |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |