| Institution: | (1) Bioinformatics Program and Center for Advanced Biotechnology, Boston University, Boston, MA 02215, USA;(2) Children's Hospital, University of Munich, Lindwurmstrasse 4, 80337 Munich, Germany;(3) SEQUENOM, Inc., San Diego, CA 92121, USA |
| Abstract: | Background For a diploid organism such as human, the two alleles of a particular gene can be expressed at different levels due to X chromosome
inactivation, gene imprinting, different local promoter activity, or mRNA stability. Recently, imbalanced allelic expression
was found to be common in human and can follow Mendelian inheritance. Here we present a method that employs real competitive
PCR for allele-specific expression analysis. |
