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Anti-inflammatory activity of constituents from Glechoma hederacea var. longituba |
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| Authors: | Kim JinPyo Song SeokBean Lee IkSoo Kim YoungHo Yoo IckDong Ryoo InJa Bae KiHwan |
| Affiliation: | a College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea b Diabetic Complications Research Center, Division of Traditional Korean Medicine Integrated Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea c Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea |
| Abstract: | Rosmarinic acid, its analogues, and a phenolic compound were obtained from G. hederacea var. longituba. There were two new compounds, methyl isoferuloyl-7-(3,4-dihydroxyphenyl) lactate (1) and benzyl-4′-hydroxy-benzoyl-3′-O-β-d-glucopyranoside (4), and four known compounds (2, 3, 5 and 6). The structures of these compounds were determined on the basis of spectroscopic methods. Each compound was tested by NF-κB luciferase assay and three rosmarinic acid analogues inhibited NF-κB production and the induction of COX-2 and iNOS mRNA in HepG2 cells. |
| Keywords: | Glechoma hederacea Inflammation Rosmarinic acid Nf-κB COX-2 iNOS |
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