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Development of 2,4-diaminopyrimidine derivatives as novel SNSR4 antagonists |
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| Authors: | Bayrakdarian Malken Butterworth Joanne Hu Yun-Jin Santhakumar Vijayaratnam Tomaszewski Mirosław J |
| Affiliation: | a Department of Medicinal Chemistry, AstraZeneca R&D Montreal, 7171 Frederick-Banting, Montréal, Québec, Canada H4S 1Z9 b Department of Invitro Biology and Drug Metabolism and Pharmaco Kinetic, AstraZeneca R&D Montreal, 7171 Frederick-Banting, Montréal, Québec, Canada H4S 1Z9 |
| Abstract: | 2,4-Diaminopyrimidines derivatives were developed as a novel class of SNSR4 antagonists. Structure activity relationship of the diamino pyrimidine core was explored and a tool compound suitable for target validation was identified. |
| Keywords: | SNSR4 MrgX1 Sensory neuron specific receptor Diamino pyrimidine BAM 8-22 |
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