Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate,cell-permeable inhibitor of cAMP-dependent protein kinase |
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| Authors: | Viht Kaido Padari Kärt Raidaru Gerda Subbi Juhan Tammiste Indrek Pooga Margus Uri Asko |
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| Affiliation: | Institute of Organic and Bioorganic Chemistry, University of Tartu, 2 Jakobi St., 51014, Tartu, Estonia. |
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| Abstract: | An adenosine-oligoarginine conjugate (ARC) was assembled in a stepwise manner on a poly(ethylene glycol) carrier. The pegylated conjugate inhibited cAMP-dependent protein kinase with IC(50)=460 nM and the cellular uptake of its BODIPY FL derivative was demonstrated and compared to that of free ARC with fluorescence microscopy. |
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