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In vitro inhibition of Helicobacter pylori by micromycetes |
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| Authors: | Stamatis George Ranci? Ana Sokovi? Marina Vukojevi? Jelena Kyriazopoulos Panayiotis Triantaphyllidis Spyros Skaltsas Spyros Skaltsa Helen |
| Institution: | Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, Panepistimiopolis, Zografou, 15771 Athens, Greece. |
| Abstract: | The anti-Helicobacter pylori effect of 22 micromycetes were studied against one standard strain and 11 clinical isolates of H. pylori. Penicillium ochlochloron and Penicillium funiculosum have been proven the most active fungi against this microorganism. Further bio-guided chemical analysis of P. funiculosum afforded an active component identified as (-) 2,3,4-trihydroxybutanamide. |
| Keywords: | Anti-Helicobacter pylori activity Micromycetes (+) 2 3 4-trihydroxy-butanamide |
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