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H NMR study on the interaction between trans-Cl2Pd(dipeptide)2 (dipeptide is glyglyOH and gly-L-nvalOH) and the dodecanucleotide [d(CGCGAATTCGCG)]2 |
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| Authors: | E. Katsarou A. Kolstad N. Hadjiliadis E. Sletten |
| Affiliation: | a Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece b Department of Chemistry, University of Bergen, Norway |
| Abstract: | The metal binding properties of trans-Cl2Pd(glyglyOH)2 and trans-Cl2Pd(glynvalOH)2 towards the oligonucleotide dodecamer [d(CGCGAATTCGCG)]2 duplex, have been studied by 1D and 2D 1H NMR spectroscopy. A selective binding of the metal with G4, followed by G2 was observed with both complexes. This indicates that an intrastrand GNG(G2C3G4)(N7-N7) chelation of Pd(II) with the dodecamer duplex may have taken place. The Pd(II)-duplex interaction is less aggressive with trans-Cl2Pd(glynvalOH)2, than with trans-Cl2Pd(glyglyOH)2. NOE connectivities in the first case show a through space hydrophobic ligand–ligand interaction of the dipeptide and oligonucleotide protons. |
| Keywords: | Dipeptide Trans-Cl2Pd(dipeptide)2 GlyglyOH Gly-l-nvalOH Dodecanucleotide [d(CGCGAATTCGCG)]2 Palladium complexes |
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