HPLC studio: a novel software utility to perform HPLC chromatogram comparison for screening purposes |
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Authors: | García J B Tormo José R |
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Institution: | Centro de Investigación Básica (CIBE), Merck, Sharp & Dohme Espa?a, Madrid, Spain. juan_bautista_garcia@merck.com |
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Abstract: | A new tool, HPLC Studio, was developed for the comparison of high-performance liquid chromatography (HPLC) chromatograms from microbial extracts. The new utility makes it possible to create a virtual chromatogram by mixing up to 20 individual chromatograms. The virtual chromatogram is the first step in establishing a ranking of the microbial fermentation conditions based on either the area or diversity of HPLC peaks. The utility was used to maximize the diversity of secondary metabolites tested from a microorganism and therefore increase the chances of finding new lead compounds in a drug discovery program. |
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