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Effect of opioids on delayed neuronal death in the gerbil hippocampus |
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| Authors: | Tomohiko Iwai Masayuki Niwa Masaya Nakashima Toshimitsu Kambara Hiromu Yamada Kaito Tsurumi and Masakatsu Nozaki |
| Institution: | 1 Department of Neurosurgery, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu, Japan 2 Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu, Japan |
| Abstract: | The effect of opioids on delayed neuronal death was evaluated in the gerbil hippocampus. Male Mongolian gerbils were subjected to transient forebrain ischemia and neuronal density was evaluated in the hippocampus 7 days following ischemia. When hypothermia during and after ischemia was prevented treatment with morphine, U-50488H, or naloxone provided no significant protection. In contrast, a spontaneous drop in rectal temperature to 32°C at the end of ischemia produced near-complete protection of CA1 pyramidal neurons. No opioids modulate the protective effect of hypothermia. |
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