Clustered GATA repeats (Bkm sequences) on the human Y chromosome |
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Authors: | J Arnemann Sibylle Jakubiczka J Schmidtke Renate Schäfer J T Epplen |
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Institution: | (1) Institut für Humangenetik der Universität, Gosslerstrasse 12D, D-3400 Göttingen, Germany;(2) Junfor Research Unit, Max-Planck-Institut für Immunbiologie, Stübeweg 51, D-7800 Freiburg, Germany |
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Abstract: | Summary Sixty eight individual clones of a human Y chromosome cosmid library were screened for the presence of GATA. repeats, the major component of Bkm-related DNA sequences. Nine cosmid clones were found to cross-hybridize. The sequence organization of the repetitive base quadruplet GATA was analyzed using synthetic oligonucleotide probes. Subclones of GATA-positive cosmid clones were used for chromosomal localization of the Y-derived DNA sequences thus revealing male-specificity or male-female homology. |
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