Characterization of the cytoskeleton in human normal and otosclerotic osteoblast-like cells. |
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| Authors: | N Arena G Venti E Becchetti T Baroni E Donti G Paludetti M Bodo |
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| Institution: | Istituto di Istologia ed Embriologia generale, Università di Sassari, Italia. |
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| Abstract: | The localization and distribution of some cytoskeletal protein components were studied by immunostaining methods in normal and ostosclerotic osteoblast-like cells. The protein components investigated were microtubules (beta-tubulin), intermediate filaments (vimentin), microfilaments (actin and myosin) and structural proteins (alpha-actinin and fibronectin). Although the mechanism is not yet clear, the alterations observed in the pathological cells could well play a role in the expression of otosclerosis. |
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