Asymmetric cell division in the morphogenesis of <Emphasis Type="Italic">Drosophila melanogaster</Emphasis> macrochaetae |
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| Authors: | T A Bukharina D P Furman |
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| Institution: | (1) Department of Biology, University College London, Gower Street, London WC1E 6BT, UK;(2) Temasek Lifesciences Laboratory, The National University of Singapore, 117604 Singapore, Singapore;(3) MRC Centre for Developmental Neurobiology, King's College London, London, UK |
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| Abstract: | Asymmetric cell division (ACD) is the basic process which creates diversity in the cells of multi-cellular organisms. As a
result of asymmetric cell division, daughter cells acquire the ability to differentiate and specialize in a given direction,
which is different from that of their parent cells and from each other. This type of division is observed in a wide range
of living organisms from bacteria to vertebrates. It has been shown that the molecular-genetic control mechanism of ACD is
evolutionally conservative. The proteins involved in the process of ACD in different kinds of animals have a high degree of
homology. Sensory organs—bristles (macrochaetae)—of Drosophila are widely used as a model system for studying the genetic
control mechanisms of asymmetric division. Bristles located in an orderly manner on the head and body of the fly play the
role of mechanoreceptors. Each of them consists of four specialized cells—offspring of the only sensory organ precursor cell
(SOP), which differentiates from the wing imaginal disc at the larval stage of the late third age. The basic differentiation
and further specialization of the daughter cells of SOP is an asymmetric division process. |
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