Temporal Distribution of [3H]-Imipramine Binding in Rat Brain Regions is Not Changed by Chronic Methamphetamine |
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Authors: | Kurt Kraeuchi Anna Wirz-Justice Tadaomi Morimasa Rosi Suetterlin-Willener Hans Feer |
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Institution: |
a Psychiatric University Clinic, Basel, Switzerland
b Institute for Neurobiology, Okayama University Medical School, Japan |
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Abstract: | Specific binding of 3H]-imipramine in the rat suprachiasmatic nuclei, occipital cortex and caudate putamen underwent significant and replicable changes throughout 24 hr under a light-dark cycle or under constant conditions. Daily variations were also found in the medial and dorsal raphe nuclei and the lateral hypothalamus. Methamphetamine, a psychoactive drug with marked effect on circadian rhythms in physiological and hormonal parameters and adrenergic receptors, did not have any significant effect on imipramine binding rhythms in eight discrete brain regions. Thus a drug known to reduce serotoninergic neurotransmission did not change characteristics of the modulatory binding site related to serotonin uptake. |
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Keywords: | Circadian rhythms imipramine binding rat brain methamphetamine |
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