Multiple tubulin forms in ciliated protozoan Tetrahymena and Paramecium species |
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Authors: | L Libusová P Dráber |
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Institution: | (1) Department of Animal Physiology and Developmental Biology, Faculty of Sciences, Charles University, Prague;(2) Department of Biology of the Cytoskeleton, Institute of Molecular Genetics, Czech Academy of Sciences, Prague |
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Abstract: | Summary. Tetrahymena and Paramecium species are widely used representatives of the phylum Ciliata. Ciliates are particularly suitable model organisms for studying
the functional heterogeneity of tubulins, since they provide a wide range of different microtubular structures in a single
cell. Sequencing projects of the genomes of members of these two genera are in progress. Nearly all members of the tubulin
superfamily (α-, β-, γ-, δ-, ɛ-, η-, θ-, ι-, and κ-tubulins) have been identified in Paramecium tetraurelia. In Tetrahymena spp., the functional consequences of different posttranslational tubulin modifications (acetylation, tyrosination and detyrosination,
phosphorylation, glutamylation, and glycylation) have been studied by different approaches. These model organisms provide
the opportunity to determine the function of tubulins found in ciliates, as well as in humans, but absent in some other model
organisms. They also give us an opportunity to explore the mechanisms underlying microtubule diversity. Here we review current
knowledge concerning the diversity of microtubular structures, tubulin genes, and posttranslational modifications in Tetrahymena and Paramecium species.
Correspondence and reprints: Institute of Molecular Genetics, Czech Academy of Sciences, Vídeňská 1083, 14220 Prague, Czech
Republic. |
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Keywords: | : Microtubule Tubulin Posttranslational modification Ciliate Paramecium tetraurelia Tetrahymena spp |
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