Metabolism of oral cephalothin and related cephalosporins in the rat |
| |
Authors: | Sullivan H R McMahon R E |
| |
Institution: | Lilly Research Laboratories, Indianapolis, Ind. 46206, U.S.A. |
| |
Abstract: | The fate of orally administered 14C]cephalothin has been studied in the rat. This antibiotic undergoes degradation in the gut followed by the subsequent absorption of a portion of the degradation products. About 50% of the administered radioactivity appears in the urine as a mixture of thienylacetylglycine, thienylacetamidoethanol and an unidentified polar metabolite. Evidence is presented indicating that thienylacetamidoethanol arises by the enzymic reduction of a metabolic intermediate, thienylacetamidoacetaldehyde. The metabolic fate of cephalothin is very similar to that of cephaloram reported earlier. The fate of 14C]cephaloridine and 7-phenoxy1-14C]acetamidocephalosporin was also investigated. In addition to the expected metabolites, about 5% of the cephaloridine dose is absorbed unchanged. With 7-phenoxy1-14C]acetamidocephalosporin, 15% of the dose is recovered in urine as deacetyl-7-phenoxy1-14C]acetamidocephalosporin. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|