SAR of 3,4-dihydropyrido[3,2-d]pyrimidone p38 inhibitors |
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| Authors: | Liu Luping Stelmach John E Natarajan Swaminathan R Chen Meng-Hsin Singh Suresh B Schwartz Cheryl D Fitzgerald Catherine E O'Keefe Stephen J Zaller Dennis M Schmatz Dennis M Doherty James B |
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| Institution: | Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. luping_liu@merck.com |
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| Abstract: | Development for a class of potent 3,4-dihydropyrido(3,2-d)pyrimidone inhibitors of p38a MAP kinase is described. Modification of N-1 aryl and C-6 arylsulfide in 3,4-dihydropyrido(3,2-d)pyrimidone analogues for the interaction with the hydrophobic pockets in p38 active site is also discussed. |
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