Conservation of key members in the course of the evolution of the insulin signaling pathway |
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Authors: | Piñero González Janet Carrillo Farnés Olimpia Vasconcelos Ana Tereza R González Pérez Abel |
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Affiliation: | Departamento de Bioquímica, Universidad de la Habana, Calle 25 # 455, esquina I, CP. 10400, Plaza, Ciudad de la Habana, Cuba. janet@fbio.uh.cu |
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Abstract: | Our understanding of the evolution of the insulin signaling pathway (ISP) is still incomplete. One intriguing unanswered question is the explanation of the emergence of the glucostatic role of insulin in mammals. To find out whether this is due to the development of new sets of signaling transduction elements in these organisms, or to the establishment of new interactions between pre-existing proteins, we rebuilt putative orthologous ISPs in 17 eukaryotic organisms. Then, we computed the conservation of orthologous ISPs at different levels, from sequence similarity of orthologous proteins to co-evolution of interacting domains. We found that the emergence of glucostatic role in mammals can neither be explained by the development of new sets of signaling elements, nor by the establishment of new interactions between pre-existing proteins. The comparison of orthologous IRS molecules indicates that only in mammals have they acquired their complete functionality as efficient recruiters of effector sub-pathways. |
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Keywords: | boldFont" >ACC, acetyl-coenzyme A carboxylase beta boldFont" >ANG, Anopheles gambiae boldFont" >APM, Apis mellifera boldFont" >BAD, BCL2-antagonist of cell death boldFont" >BTA, Bos taurus boldFont" >CEL, Caenorhabditis elegans boldFont" >CFA, Cannis familiaris boldFont" >CIN, Ciona intestinalis boldFont" >DME, Drosophila melanogaster boldFont" >DRE, Danio rerio boldFont" >FRU, Fugu rubripes boldFont" >G6PC, glucose-6-phosphatase boldFont" >GAL, Gallus gallus boldFont" >GYS, glycogen synthase boldFont" >FAS, fatty acid synthase complex boldFont" >HK, hexoquinase boldFont" >HMM, Hidden Markov Models boldFont" >HSA, Homo sapiens boldFont" >IGF, insulin-like growth factor boldFont" >IRS, insulin receptor substrate boldFont" >ISP, insulin signaling pathway boldFont" >MAPK, mitogen activated protein/microtubule-associated protein boldFont" >MOD, Monodelphis domestica boldFont" >MUS, Mus musculus boldFont" >ORF, open reading frame boldFont" >PH, pleckstrin homology boldFont" >PHK, phosphorylase kinase boldFont" >PI3K, phosphoinositide-3-kinase boldFont" >PKA, protein kinase, cAMP-dependent boldFont" >PP1, protein phosphatase 1 boldFont" >PTB, phosphotyrosine binding domain boldFont" >PTR, Pan troglodytes boldFont" >RNO, Rattus norvegicus boldFont" >SH2, Src homology 2 domain boldFont" >TEN, Tetraodon nigroviridis boldFont" >XET, Xenopus tropicalis |
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