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7S class-restricted hapten-specific paralysis by injection of thymus-independent hapten-carrier conjugate. |
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| Authors: | P Del Guercio M F Poirier N Thobie |
| Abstract: | The shift from IgM anti-hapten antibody production to IgG anti-hapten antibody production, subsequent to challenge with a T-dependent conjugate, is inhibited in mice by preimmunization with the T-independent DNP-LE conjugate. The results suggest that DNP on levan triggers off 19A T-independent anti-hapten precursors and paralyzes 7S T-dependent anti-hapten precursors. |
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