Model synthesis of nucleoside boranophosphoramidate with amino acid for prodrug purpose |
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Authors: | Li Ping Shaw Barbara Ramsay |
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Institution: | Department of Chemistry, Duke University, Box 90346, Durham, NC 27708-0346, USA. |
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Abstract: | A model synthesis of a nucleoside boranophosphoramidate prodrug with (L)-tryptophan methyl ester was accomplished in a one-pot reaction via an H-phosphonate approach. This new type of compound is expected to possess the potent antiviral and anticancer advantages conferred by boranophosphates and normal nucleoside amino acid phosphoramidate. |
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