Interaction of cholesterol-conjugated alkylating oligonucleotide derivatives with cellular biopolymers. |
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| Authors: | A S Ryte V N Karamyshev M V Nechaeva Z V Guskova E M Ivanova V F Zarytova V V Vlassov |
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| Institution: | Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk. |
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| Abstract: | Interactions of oligonucleotide derivatives with mammalian cells and cellular biopolymers have been investigated. The derivatives were oligonucleotides bearing an alkylating 2-chloroethylamino group at the 3'-end and a cholesterol residue at the 5'-terminal phosphate. These compounds are readily taken up by cells and react with cellular DNA, RNA and some proteins which may play a role in delivery of the compounds into cells. |
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