Effect of selenium supplementation on some blood biochemical parameters in male rats |
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Authors: | A M Viegas Crespo M J Lança S Vasconcelos V Andrade H Rodrigues M C Santos |
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Institution: | (1) Departmento de Zoologia e Antropologia, Faculdade de Ciências de Lisboa, Bloco C-2, 3\dg piso, Campo Grande, 1700 Lisboa, Portugal;(2) Departmento de Química, Faculdade de Ciências de Lisboa, Lisboa, Portugal |
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Abstract: | The long-term effect of selenium supplementation on blood glutathione peroxidase (GSH-Px) activity and plasma TBARS’ production
(as an index of peroxidation) was evaluated in 15-mo-old male rats fed a diet supplemented with 0.25 or 0.50 ppm selenium,
for 12 mo. A group of nonsupplemented age-matched rats was the control. In addition, triglycerides, phospholipids, total and
free cholesterol, HDL-cholesterol, and HDL-phospholipid levels were measured in plasma. Plasma testosterone levels were also
determined in order to control the aging process in these animals.
The GSH-Px activity and the peroxidation level were unchanged in all the groups. However, concerning the lipid parameters,
a decrease in triglycerides concentration was observed in both treated groups (p<0.05). Therefore, in these experimental conditions, despite no observed changes in parameters related to lipid peroxidation,
selenium seems to be involved with triglycerides metabolism, eventually improving the triglycerides status of aged animals. |
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Keywords: | Rat selenium glutathione peroxidase peroxidation index cholesterol triglycerides phospholipids |
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