Ionic liquid anchored substrate for enzyme catalysed kinetic resolution

A hydroxyl group appended task specific ionic liquid was designed and synthesised. The ionic liquid was used as a vehicle for the substrate of our interest for lipase catalysed kinetic resolution. The ionic liquid anchored ibuprofen underwent Candida antarctica lipase catalysed hydrolysis yielding the S-enantiomer. The strategy facilitated easy post-resolution isolation of the enantiomers and also carries the prospect of recyclability.