Toxoplasma gondii: immunogenicity and protection by P30 peptides in a murine model |
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Authors: | Siachoque Heber Guzman Fanny Burgos Javier Patarroyo Manuel Elkin Gomez Marin Jorge Enrique |
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Institution: | Laboratorio de Inmunologia, Facultad de Medicina, Universidad del Rosario, Bogota, Colombia. |
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Abstract: | Vaccines are promising for the control of toxoplasmosis. Here, we evaluated the immunogenicity of 17 peptides derived from SAG1 surface protein of Toxoplasma gondii in CH3 mice. Only 8 of 16 peptides induced specific antibodies. After a lethal challenge, only the vaccination with 4 of 17 peptides that were from the carboxy terminal end of the protein conferred significant survival. Our work shows that vaccination with peptides from the carboxy-terminal positions of SAG1 major surface protein of Toxoplasma protects mice against a lethal challenge. |
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Keywords: | Toxoplasma gondii Peptides Vaccines SAG1 P30 Murine model |
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