Caldesmon and smooth-muscle regulation |
| |
| Authors: | C -L Albert Wang |
| |
| Institution: | (1) Muscle and Motility Group, Boston Biomedical Research Institute, 64 Grove Street, 02472 Watertown, MA |
| |
| Abstract: | Smooth muscles exist in the wall of hollow organs in our body and are responsible for controlling the flow of vital fluids
that are essential for the normal function of the cardiovascular, respiratory, digestive, and reproductive systems. Many diseases,
such as hypertension, asthma, indigestion, and premature birth, may attribute to malfunction of smooth-muscle contraction.
It is therefore important to decipher how smooth-muscle contraction is regulated. This review attempts to give a brief overview
of current understanding about the molecular mechanisms of smooth-muscle regulation and, in particular, to discuss possible
roles of caldesmon in this regulatory process. |
| |
| Keywords: | Actin-binding proteins Caldesmon Calmodulin dense body electron microscopy intracellular localization latch state smooth muscle synthetic peptides thin filament-based regulation |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
