Detecting sequence polymorphisms associated with meiotic recombination hotspots in the human genome |
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| Authors: | Jie Zheng Pavel P Khil R Daniel Camerini-Otero Teresa M Przytycka |
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| Institution: | (1) Computational Biology Branch, NCBI, NLM, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA;(2) Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, 5 Memorial Drive, Bethesda, Maryland 20892, USA |
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| Abstract: | Background Meiotic recombination events tend to cluster into narrow spans of a few kilobases long, called recombination hotspots. Such
hotspots are not conserved between human and chimpanzee and vary between different human ethnic groups. At the same time,
recombination hotspots are heritable. Previous studies showed instances where differences in recombination rate could be associated
with sequence polymorphisms. |
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