首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Detecting sequence polymorphisms associated with meiotic recombination hotspots in the human genome
Authors:Jie Zheng  Pavel P Khil  R Daniel Camerini-Otero  Teresa M Przytycka
Institution:(1) Computational Biology Branch, NCBI, NLM, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA;(2) Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, 5 Memorial Drive, Bethesda, Maryland 20892, USA
Abstract:

Background  

Meiotic recombination events tend to cluster into narrow spans of a few kilobases long, called recombination hotspots. Such hotspots are not conserved between human and chimpanzee and vary between different human ethnic groups. At the same time, recombination hotspots are heritable. Previous studies showed instances where differences in recombination rate could be associated with sequence polymorphisms.
Keywords:
本文献已被 PubMed SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号