Cytogenetic mechanisms of aneuploidy in somatic cells of chemonuclear industry professionals with incorporated plutonium-239 |
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| Authors: | S A Vasilyev V A Timoshevsky I N Lebedev |
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| Institution: | (1) School of Molecular Biosciences, Fulmer Hall 539, Washington State University, Mail drop 644660, Pullman, WA 99164-4660, USA;(2) Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA;(3) The Jackson Laboratory, Bar Harbor, ME 04609, USA |
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| Abstract: | Risks related to occupational exposure of humans to ionizing radiation remains a focus of attention. Of special importance
is the poorly understood effect of ionizing radiation on the rate of numerical chromosome aberrations in human somatic cells.
The purpose of this study was characterization of a radiation-induced increase in the rate of aneuploidy induced by incorporated
plutonium-239 (239Pu) in somatic cells of chemonuclear industry workers. Significant differences in the chromosome 2, 7, 8, 12, and Y aneuploidy
rate have been found between subjects with incorporated 239Pu and control subjects have been demonstrated. Chromosome nondisjunction has been found to be the main mechanism of aneuploidy
induced by incorporated 239Pu. |
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