Predicting direct protein interactions from affinity purification mass spectrometry data |
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| Authors: | Ethan DH Kim Ashish Sabharwal Adrian R Vetta Mathieu Blanchette |
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| Affiliation: | 1.McGill Centre for Bioinformatics, McGill University,Quebec,Canada;2.Department of Computer Science,Cornell University,USA;3.Department of Mathematics and Statistics,McGill University,Quebec,Canada |
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| Abstract: | Background Affinity purification followed by mass spectrometry identification (AP-MS) is an increasingly popular approach to observe protein-protein interactions (PPI) in vivo. One drawback of AP-MS, however, is that it is prone to detecting indirect interactions mixed with direct physical interactions. Therefore, the ability to distinguish direct interactions from indirect ones is of much interest. |
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