Dynamic neuroplasticity after human prefrontal cortex damage |
| |
Authors: | Voytek Bradley Davis Matar Yago Elena Barceló Francisco Vogel Edward K Knight Robert T |
| |
Affiliation: | Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA. bradley.voytek@gmail.com |
| |
Abstract: | Memory and attention deficits are common after prefrontal cortex (PFC) damage, yet people generally recover some function over time. Recovery is thought to be dependent upon undamaged brain regions, but the temporal dynamics underlying cognitive recovery are poorly understood. Here, we provide evidence that the intact PFC compensates for damage in the lesioned PFC on a trial-by-trial basis dependent on cognitive load. The extent of this rapid functional compensation is indexed by transient increases in electrophysiological measures of attention and memory in the intact PFC, detectable within a second after stimulus presentation and only when the lesioned hemisphere is challenged. These observations provide evidence supporting a dynamic and flexible model of compensatory neural plasticity. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|