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Design of a novel class of biphenyl CETP inhibitors |
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| Authors: | Lu Zhijian Napolitano Joann B Theberge Ashleigh Ali Amjad Hammond Milton L Tan Eugene Tong Xinchun Xu Suoyu S Latham Melanie J Peterson Laurence B Anderson Matt S Eveland Suzanne S Guo Qiu Hyland Sheryl A Milot Denise P Chen Ying Sparrow Carl P Wright Samuel D Sinclair Peter J |
| Institution: | Department of Medicinal Chemistry, Merck Sharp & Dohme Corp., Rahway, NJ 07065, USA. zhijian_lu@merck.com |
| Abstract: | A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model. |
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