Inferring topology from clustering coefficients in protein-protein interaction networks |
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Authors: | Caroline C Friedel and Ralf Zimmer |
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Affiliation: | (1) LFE Bioinformatik, Institut f?r Informatik, Ludwig-Maximilians-Universit?t M?nchen, Amalienstra?e 17, 80333 M?nchen, Germany |
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Abstract: | Background Although protein-protein interaction networks determined with high-throughput methods are incomplete, they are commonly used to infer the topology of the complete interactome. These partial networks often show a scale-free behavior with only a few proteins having many and the majority having only a few connections. Recently, the possibility was suggested that this scale-free nature may not actually reflect the topology of the complete interactome but could also be due to the error proneness and incompleteness of large-scale experiments. |
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